Finasteride Powder Anti Estrogen Steroids 98319-26-7 Treating Prostate

Anti Estrogen Steroids Finasteride White Powder 98319-26-7 for Treating Prostate Enlargement

Basic Information:

Product Name: Finasteride(Propecia)
Synonym: FINASTERIDE; FINASTID; ; Propecia
CAS No.: 98319-26-7
Molecular formula: C23H36N2O2
Molecular weight: 372.54
Packing: 1KG/Bag
Content: 99%
Appearance: White powder
Grade: Pharmaceutical grade

COA:

Product name	Finasteride
CAS No.	98319-26-7	Outer Packing	1KG/drum
Production date	Jun.,01, 2016	Shelf life	May.,31, 2021
Standard adopted	USP38
Items of analysis	Specification	Results
Description	white or almost white crystalline powder	almost white crystalline powder
Identification(IR,HPLC)	complies with the standard	complies
Solubility	Free soluble in chloroform and in alcohol ,very slightly soluble in water.	complies
Melting point	About 257℃	256.0～257.0℃
Specific rotation	-56.0°～-60.0°	-58.4°
Water	max.0.3%	0.25%
Residue on ignition	max.0.1%	0.04%
Heavy Metals	max.10ppm	complies
Loose Density (g/cm3)	0.27～0.37	0.31
Tapped Density (g/cm3)	0.40～0.56	0.52
Particle size	100%≤20um 90%≤10um	complies
Any individual impurity	max.0.5%	0.12%
Total impurities	max.1.0%	0.44%
Assay (HPLC, based on drying)	98.5%～101.0%	99.2%
Acetone	Max.5000ppm	complies
Chloroform	Max.60ppm	complies
THF	Max.720ppm	complies
Dichloromethane	Max.600ppm	complies
Toluene	Max.890ppm	complies
Methanol	Max3000ppm	complies
Organic volatile substances	Meet the ICH requirements	complies
Conclusion	Qualified

What is finasteride, and how does it work (mechanism of action)?

The prostate gland is located around the tube which empties urine from the bladder (urethra). As the prostate gland enlarges, usually after 50 years of age, it can obstruct or partially block the urine flow. This leads to symptoms which include dribbling of urine, narrow stream, problems starting urine flow, interruption while urinating, and a feeling of incomplete emptying. Other symptoms include wetting and staining of clothes, urinary burning, and urgency.

Prostate gland enlargement (benign prostatic hyperplasia or BPH), is directly dependent on DHT (a hormone converted from the male hormone testosterone). Finasteride inhibits the enzyme necessary for the conversion of testosterone to DHT in the prostate. Therefore, administration of finasteride lowers blood and tissue DHT levels and helps reduce the size of the prostate gland.

Medical uses:

Prostate enlargement:

Physicians sometimes use finasteride for the treatment of BPH, informally known as an enlarged prostate. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow. It provides less symptomatic relief than alpha-1 blockers such as tamsulosin and symptomatic relief is slower in onset (six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment). Symptomatic benefits are mainly seen in those with prostate volume > 40 cm3. In long-term studies finasteride but not alpha-1 inhibitors reduce the risk of acute urinary retention (−57% at 4 years) and the need for surgery (−54% at 4 years). If the drug is discontinued, any therapeutic benefits reverse within about 6-8 months.

Pattern hair loss:

Finasteride is sometimes used to treat pattern hair loss (androgenetic alopecia) in men only.Treatment slows further hair loss and provides about 30% improvement in hair loss after six months of treatment, with effectiveness usually only persisting as long as the drug is taken, although on occasion hair loss is slowed indefinitely following withdrawal. Finasteride has also been tested for pattern hair loss in women; the results were no better than placebo.

Before taking finasteride:

tell your doctor and pharmacist if you are allergic to finasteride, any other medications, or any of the ingredients in finasteride tablets. Ask your pharmacist or check the patient information for a list of the ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had liver disease or prostate cancer.

you should know that finasteride is only for use in men. Women, especially those who are or may become pregnant should not touch broken or crushed finasteride tablets. Touching broken or crushed finasteride tablets may harm the fetus. If a woman who is pregnant or who could become pregnant touches broken or crushed finasteride tablets, she should wash the area with soap and water immediately and call her doctor.

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Finasteride Powder Anti Estrogen Steroids 98319-26-7 Treating Prostate Images