AICAR Weight Loss Powder CAS 2627-69-2 , Bodybuilding Fat Loss Supplements

Healthy Fat Burning Steroids AICAR CAS: 2627-69-2 for Weight Loss White Powder

Specifications:

5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside
Chemical name:5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside
Synonyms:5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; AICAR; Acadesine; 5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide; 5-Amino-4-imidazole
carboxamide Riboside; Arasine; GP 1-110; NSC 105823.
CAS Number:2627-69-2
Molecular form.:C₉H₁₄N₄O₅
Appearance:Off-White to Pale Beige Solid
Melting Point:205-207°C (dec.)
Mol. Weight:258.23
Unit Size:50 mg/vial
Storage:-20°C Freezer
Solubility:DMSO, Methanol, Water (65 mg / mL at 23°C)
Category:Carbohydrates & Derivatives, Nucleotides, Bases & Related Reagents,
Applications: AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) have been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

HISTORY:

AICAR has been used medically to help with restriction of blood supply to tissues, called ischemia. Interestingly, in the 1980’s it was sometimes used during surgery to help preserve blood flow to the heart. These days, AICAR shows to be promising in diabetes treatment because of its ability to increase metabolic activity of tissues by changing the composition of muscles in the body.

What is AICAR?

AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.

5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has been used clinically to treat and protect against cardiac ischemic injury.The drug was first used in the 1980s as a method to preserve blood flow to the heart during surgery.Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.

How it works ?

Acadesine is an analog of adenosine that enters cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia.In cardiac myocytes, acadesine is phosphorylated to AICAR to activate AMPK without changing the levels of the nucleotides. AICAR is able to enter the de novo synthesis pathway for adenosine synthesis to inhibit adenosine deaminase causing an increase in ATP levels and adenosine levels.

How AICAR Functions:

Scientific study based on animal test subjects has detmined that AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide’s presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

Ultimately, all of these elevated processes combine to provide an animal test subject an easier time in which it can achieve a level of homeostasis.

Applications and benefits:

Medical use:

A brief period of coronary arterial occlusion followed by reperfusion prior to prolonged ischemia is known as preconditioning. It has been shown that this is protective. Preconditioning preceded myocardial infarction, may delay cell death and allow for greater salvage of myocardium through reperfusion therapy.AICAR has been shown to precondition the heart shortly before or during ischemia.AICAR triggers a preconditioned anti-inflammatory state by increasing NO production from endothelial nitric oxide synthase.When AICAR is given 24 hours prior to reperfusion, it prevents post ischemic leukocyte-endothelial cell adhesive interactions with increased NO production. AICAR-dependent preconditioning is also mediated by an ATP-sensitive potassium channel and hemeoxygenase-dependent mechanism. It increases AMPK-dependent recruitment of ATP-sensitive K channels to the sarcolemma causing the action potential duration to shorten, and preventing calcium overload during reperfusion.The decrease in calcium overload prevents inflammation activation by ROS.AICAR also increases AMPK-dependent glucose uptake through translocation of GLUT-4 which is beneficial for the heart during post-ischemic reperfusion.The increase in glucose during AICAR preconditioning lengthens the period for preconditioning up to 2 hours in rabbits and 40 minutes in humans undergoing coronary ligation.As a result, AICAR reduces the frequency and size of myocardial infarcts up to 25% in humans allowing improved blood flow to the heart.As well, the treatment has been shown to decrease the risk of an early death and improve recovery after surgery from an ischemic injury.

Use as a performance-enhancing drug:

In 2009, the French Anti-Doping Agency, suspected that AICAR had been used in the 2009 Tour de France for its weight loss, performance, and blood-oxygen boosting properties.Although a detection method was reportedly given to the World Anti-Doping Agency, it was unknown if this method was implemented.As of January 2011, AICAR was officially a banned substance in the World Anti Doping Code,and the standard levels in elite athletes have been determined, to interpret test results.

Doses:

Dosages range from 150 milligrams (mg) per day (if stacked with GW), up to 500mg a day when used solo. Considering the fact that each bottle typically comes in 50mg dosages, as already mentioned above. Economically, it makes most sense to run AICAR during the 4 weeks leading up to your competition.

Side effect:

AICAR’s side effects are very real and serious. Since it affects blood flow, AICAR can cause less blood going to your brain and heart valve issues. Hence, those side effects make AICAR one of the most risky compounds to use in the PED world. Less significant side effects, such as diarhea and thirst, are also common.

The most concerning side effects from AICAR are the direct effects it has on your heart. It can cause enlarged growth in cardiac tissue, and it can effect blood flow. In turn, this could affect the flow of blood to a person’s brain. In addition, it has been noted that defects of heart valves may also be caused by the peptide AICAR. The heart is the most important muscle in the entire body, and the last thing anyone wants to do is treat it badly. Anecdotally, some logs indicated extreme loose bowls, dry mouth, and lack of hunger.

Summary of AICAR side effects

Possible enlarged growth of heart
Possible defects to the heart valve
Problems with blood flow
Problems with blood and nutrient transfer to the brain
Problems with bowls

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AICAR Weight Loss Powder CAS 2627-69-2 , Bodybuilding Fat Loss Supplements Images