White Crystalline Powder Pramoxine Hydrochloride CAS 637-58-1 Relieve Pain /

USP Local Anesthetic Pramoxine HCL CAS: 637-58-1 Relieve Pain and Itching

 

Pramoxine hydrochloride is used as a topical anesthetic to relieve mild pain and itching. The drug was discovered in 1953 at Abbott Laboratories. The trade name of pramoxine hydrochloride is Pramocaine.

 

Quick Details:

 

Product name:Pramoxine Hydrochloride,Pramoxine HCL
English Synonyms: Proctofoam; Pramoxine HCL; Praxomine Hydrochloride; Tronothane Hydrochloride; ; pramocaine Hydrochloride;
Synonyms:4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride ; gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride ; p-butoxyphenylgamma-morpholinopropyletherhydrochloride ; proctofoam ; Pramoxine HCL ; Praxomine Hydrochloride ; Tronothane Hydrochloride ; 4-[3-(P-BUTOXYPHENOXY)PROPYL]MORPHOLINE Hydrochloride ; 4-n-butoxyphenyl gamma-morpholinopropyl ether hydrochloride ; 4-N-BUTOXYPHENYL G-MORPHOLINOPROPYL ETHER Hydrochloride ; pramocaine Hydrochloride ; 4-[3-(4-butoxyphenoxy)propyl]morpholine Hydrochloride (1:1)
CAS:637-58-1
EINECS number: 211-293-1
Molecular formula: C17H28ClNO3
Molecular weight: 329.8621
Assay:99% min
Appearance: White or almost white crystalline powder
Boiling point: 427 ° C at 760 mmHg
Flash Point: 123.5 ° C
Vapor Pressure: 1.7E-07mmHg at 25 ° C
Standard:USP
Grade:Pharmaceutical Grade
Express: EMS, DHL, FedEx, etc(door-to-door)

 

COA:

 

Melting range	170~174℃	171.7~173.2℃
Loss on drying	<1.0%	0.12%
Residue on ignition	<0.1%	0.04%
Ethanol	<0.5%	0.061%
Carbinol	<0.3%	0.10%
Acetone	<0.5%	Not detected
Assay	98.0%~102.0%	99.98%
Conclusion	The results conforms with USP33

 

Description of Pramoxine HCL:

 

Structurally, it is the esther hydrochloride of p-n butoxyphenyl gammamorpholinopropane. The substance stood out as a good topical local anesthetic agent when Abbott Laboratories were researching a series of alkoxy aryl alkamine ethers for such an application. Pramocaine is tolerable by most mucus membranes and ranks low on the sensitizing index, making it unlikely to trigger an allergic reaction.

 

Pramoxine Hydrochloride is the hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property.Pramocaine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.

Pramoxine is used to temporarily relieve itching and pain caused by minor skin irritation such as minor burns/cuts/scrapes, sunburn, eczema, insect bites, cold sores, or rashes from poison ivy, poison oak, or poison sumac. Some products containing pramoxine are also used to temporarily relieve the itching and discomfort from hemorrhoids and certain other problems of the genital/anal area (such as anal fissures, itching around the vagina/rectum).

 

Pramoxine Hydrochloride Fuction:

 

Structurally, it is the esther hydrochloride of p-n butoxyphenyl gammamorpholinopropane. The substance stood out as a good topical local anesthetic agent when Abbott Laboratories were researching a series of alkoxy aryl alkamine ethers for such an application. Pramocaine is tolerable by most mucus membranes and ranks low on the sensitizing index, making it unlikely to trigger an allergic reaction.

 

Surgical anesthesia:Epidural anesthesia (including epidural anesthesia during cesarean section);Local infiltration anesthesia.

Acute pain control:For postoperative or labor analgesia continuous epidural infusion can be used can also be intermittent medication;Local infiltration anesthesia.

Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.

 

Pramoxine HCL Dosage:

 

Pramoxine hydrochloride cream USP can be used by adults and adolescents as needed three to four times per day. The same dosing instructions can also be followed in the use of pramoxine hydrochloride lotion, pramoxine hydrochloride and menthol gel as well as pramoxine hydrochloride and menthol lotion. Proper dosing for pediatric use in children younger than two years old has not been established. Pramoxine should not be applied across large areas of the body and should not be used for extended periods of time as this may increase the risk of toxicity and systemic absorption.

 

Where Should Keep Medicine?

 

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Throw away any unused medicine after the expiration date.

 

 

 

Product List:

 

Product name	CAS NO.	Product name	CAS NO.
Benzocaine	94-09-7	Procaine	59-46-1
Dapoxetine Hydrochloride	129938-20-1	Tetracaine HCl	136-47-0
Clobetasol Propionate	25122-46-7	L-Thyroxine	51-48-9
Finasteride	98319-26-7	Dydrogesterone	152-62-5
Theophylline	58-55-9/ 5967-84-0	Valdecoxib	181695-72-7
Procaine HCl	51-05-8	Lidocaine HCl	73-78-9
Lidocaine	137-58-6	Benzocaine HCl	23239-88-5
Dapoxetine	119356-77-3	L-Epinephrine hydrochloride	55-31-2/ 329-63-5
Chloramphenicol	56-75-7/ 2787-09-9	Doxorubicin hydrochloride	25316-40-9
Omeprazole	73590-58-6/ 119141-89-8	Benzyl benzoate	120-51-4
Dutasteride	164656-23-9	Cyanocobalamin	68-19-9/18195-32-9/ 13408-78-1
Acetaminophen	103-90-2	Paromomycin	7542-37-2
Amikacin disulfate salt	39831-55-5/ 149022-22-0	Nitazoxanide	55981-09-4
Dexamethasone sodium phosphate	55203-24-2/ 312-93-6	Secnidazole	3366-95-8
Trestolone acetate	6157-87-5	Tinidazole	19387-91-8
Lincomycin hydrochloride	7179-49-9	Chlorhexidine Gluconate	18472-51-0
Clotrimazole	23593-75-1	1,3-dimethyl-pentylamine hydrochloride	105-41-9
1,3-Dimethylbutylamine hydrochloride	71776-70-7	4 amino-2-Methylpentane citrate(AMP Citrate)	71776-70-0

 

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White Crystalline Powder Pramoxine Hydrochloride CAS 637-58-1 Relieve Pain / Images