USP Local Anaesthesia Drugs Tetracaine HCL CAS 136-47-0 Pharmaceutical Raw

USP Local Anesthetic Tetracaine HCL CAS 136-47-0 Pharmaceutical Raw Powder

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Quick Details:

Product name:Tetracaine Hydrochloride;Tetracaine HCL
Synonyms: Tetracaine HCL
CAS: 136-47-0
EINECS: 205-248-5
MF: C15H25ClN2O2
MW: 300.82
Assay:99.5% min
Melting point : 149°C
Grade : Pharmaceutical Grade
Storage temp: Refrigerator
Appearance: White Solid
Usage: Local anesthetic; Mainly used in mucosa anesthetic.The function is stronger than Procaine and Lidocaine.

COA:

Test Items	Specification	Test Results
Appearance	Fine, white, crystalline, odorless powder	confirm
Identification	ABC in Pass	confirm
Solubility	Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene	confirm
USP Reference standards	USP Tetracaine Hydrochloride RS. USP Endotoxin RS.	confirm
Melting point	145~150 degree	146.0~147.5 degree
Chromatographic purity	In Pass	confirm
Related substance	Not more than the reference solution 0.05%	confirm
Heavy metals	<10ppm	confirm
PH	4.5-6.5	5.8
Residue on ignition	<0.10%	0.05%
Loss on Drying	<0.5%	0.19%
Assay	98.0 -101.0%	100.1%
Conclusion	Confirms USP 32

Description:

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

Fuction of Tetracaine Hydrochloride:

Tetracaine hydrochloride is indicated for the production of spinal anesthesia for procedures requiring two to three hours. Parenteral administration of Tetracaine hydrochloride stabilizes the neuronal membrane and prevents initiation and transmission of nerve impulses thereby effecting local anesthesia.

The onset of action is rapid, and the duration is prolonged (up to two or three hours or longer of surgical anesthesia).Tetracaine hydrochloride is detoxified by plasma esterases to aminobenzoic acid and diethylaminoethanol.

What should I watch for while using this medicine?

Do not touch, wipe or rub your eyes after application of this medicine; you could hurt the eye without feeling it. Do not try and put contact lenses in your eyes until the effect of this medicine has worn off. Follow your doctors directions.

You should not use this medicine yourself except under the direct supervision of your doctor. This medicine should not be used for prolonged periods of time. If your condition does not improve, call your health care professional.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Protect from light. Throw away any unused medicine after the expiration date. Do not use the medicine if it is cloudy or if crystals form in it.

Product List:

Product name	CAS NO.	Product name	CAS NO.
Benzocaine	94-09-7	Procaine	59-46-1
Dapoxetine Hydrochloride	129938-20-1	Tetracaine HCl	136-47-0
Clobetasol Propionate	25122-46-7	L-Thyroxine	51-48-9
Finasteride	98319-26-7	Dydrogesterone	152-62-5
Theophylline	58-55-9/ 5967-84-0	Valdecoxib	181695-72-7
Procaine HCl	51-05-8	Lidocaine HCl	73-78-9
Lidocaine	137-58-6	Benzocaine HCl	23239-88-5
Dapoxetine	119356-77-3	L-Epinephrine hydrochloride	55-31-2/ 329-63-5
Chloramphenicol	56-75-7/ 2787-09-9	Doxorubicin hydrochloride	25316-40-9
Omeprazole	73590-58-6/ 119141-89-8	Benzyl benzoate	120-51-4
Dutasteride	164656-23-9	Cyanocobalamin	68-19-9/18195-32-9/ 13408-78-1
Acetaminophen	103-90-2	Paromomycin	7542-37-2
Amikacin disulfate salt	39831-55-5/ 149022-22-0	Nitazoxanide	55981-09-4
Dexamethasone sodium phosphate	55203-24-2/ 312-93-6	Secnidazole	3366-95-8
Trestolone acetate	6157-87-5	Tinidazole	19387-91-8
Lincomycin hydrochloride	7179-49-9	Chlorhexidine Gluconate	18472-51-0
Clotrimazole	23593-75-1	1,3-dimethyl-pentylamine hydrochloride	105-41-9
1,3-Dimethylbutylamine hydrochloride	71776-70-7	4 amino-2-Methylpentane citrate(AMP Citrate)	71776-70-0

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USP Local Anaesthesia Drugs Tetracaine HCL CAS 136-47-0 Pharmaceutical Raw Images