Valsartan Local Anaesthesia Drugs CAS 137862-53-4 Treating High Blood Pressure

Valsartan CAS:137862-53-4 Raw Powder for Treating High Blood Pressure

Description:

Valsartan (trade name Diovan) is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. It is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor.

Basic information:

Chemical nmae: Valsartan
MF: C24H29N5O3
MW: 435.52
CAS: 137862-53-4
Appearance: white powder
Purity: over 99%
Package: 25KG
Usage: Treatment of hypertension

COA:

Product name	Valsartan
CAS No.	137862-53-4	Outer Packing	25kg
Production date	2017.04.21	Shelf life	2020.04.20
Standard adopted	UPS Standard
Items of analysis	Specification	Results
Description	White or grayish white powder, odorless, slightly hygroscopic	qualified
Solubility	Soluble in methanol and ethanol, slightly soluble in ethyl acetate	qualified
Identification	IR,HPLC Meet the reference standard	qualified
Absorbance at 420nm	≤0.02(at 420nm)	qualified
Warter(KF)	≤2.0%	1.01%
Residue on Ignition	≤0.1%	0.07%
Heavy Metals	≤10ppm	＜10ppm
Related compounds	Compound A ≤1.0%	0.55%
.	Compound B≤0.2%	0.06%
.	Compound C≤0.1%	N.D.
.	Any other individual impunrity ≤0.1%	0.06%
.	Total impurity ≤0.3%	0.20%
Related Solvents	Ethyl acetate≤50000ppm	3000ppm
.	Ethanol ≤50000ppm	N.D.
.	Toluene ≤890ppm	280ppm
Assay(HPLC)	98.0%~102.0%	99.5%
Conclusion	Qualified

Medical uses:

Valsartan is used to treat high blood pressure, congestive heart failure, and to reduce death for people with left ventricular dysfunction after having had a heart attack.

There is contradictory evidence with regard to treating people with heart failure with a combination of an angiotensin receptor blocker like valsartan and an angiotensin-converting enzyme inhibitor, with two major clinical trials (CHARM-additive and ValHeFt) showing a reduction in death, and two others (VALIANT and ONTARGET) showing no benefits, and more adverse effects including heart attacks.

In people with type II diabetes and high blood pressure or albumin in the urine, valsartan is used to slow the worsening and the development end-stage renal disease.

How to use Valsartan:

Read the Patient Information Leaflet if available from your pharmacist before you start taking valsartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.

If you are using the liquid form of this medication, shake the bottle well for at least 10 seconds before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Tell your doctor if you do not get better or if you get worse (for example, your blood pressure readings remain high or increase).

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