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Home>Products>Local Anaesthesia Drugs>Yellow Powder Local Anaesthesia Drugs Antibacterial Medicine Furacilin CAS 59-87

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  • Yellow Powder Local Anaesthesia Drugs Antibacterial Medicine Furacilin CAS 59-87
  • Yellow Powder Local Anaesthesia Drugs Antibacterial Medicine Furacilin CAS 59-87
  • Yellow Powder Local Anaesthesia Drugs Antibacterial Medicine Furacilin CAS 59-87
  • Yellow Powder Local Anaesthesia Drugs Antibacterial Medicine Furacilin CAS 59-87

Yellow Powder Local Anaesthesia Drugs Antibacterial Medicine Furacilin CAS 59-87

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  • 59-87-0

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Product Details

CAS number: 59-87-0 MF: C6H6N4O4 MW: 198.14
Appearance: white powder Purity: ≥98% Usage: Increasing Memory

Product Description

Antibacterial Medicine Furacilin CAS 59-87-0 Yellow Powder 99% Purity

Basic information:

CAS No.59-87-0
Chemical Name:Furacilin
Synonyms: NF;NFZ;NFS;NF-7;Nefco;acutol;Amifur;Chixin;Mammex;U-6421
CBNumber: CB0492724
Molecular Formula:C6H6N4O4
Formula Weight:198.14
Melting point:242-244 °C(lit.)
Flash point: 2 °C
storage temp: 2-8°C
Water Solubility: <0.1 g/100 mL at 19 ºC
Sensitive: Light Sensitive
Merck: 14,6600

COA:

Product name Furacilin
CAS No. 59-87-0 Outer Packing

25KG

Production date 17.5 Shelf life 20.5
Standard adopted

BP2015

Items of analysis Specification Results

Appearance

A yellow or brownish-yellow,Crystalline powder

Conforms

A

Carry out the test protected from bright light. Use

Appearance

A yellow or brownish-yellow,Crystalline powder,

Conforms

A

Carry out the test protected from bright light.use the solution prepared for the assay.examined between 220 nm and 400 nm(2.2.25),the solution shows two absorption maxima ,at 260 nm and 375nm.The ratio of the absorbance measured at the maximum at 375 nm to that measured at the maximum at 260 nm is 1.15 to 1.13

Conforms

B

Examine by infrared absorption spectrophotometry (2.2.24), comparing with the spectrum obtained with nitrofural CRS. Examine the substances prepared as discs.

Conforms

C

Examine by thin-layer chromatography (2.2.27),using silica gel G R as the coating substance.

Conforms

D

Dissolve about 1 mg in 1 ml of dimethylformamide R and add 0.1 ml of alcoholic potassium hydroxide solution R. A violet-red colour is produced.

Conforms

PH:

5.0~7.0

6.22

5-nitro-2-furfuraldizine

Not more than 0.5%

Conforms

Individual impurity

Not more than 0.5%

Conforms

Total impurities

Not more than 1.0%

Conforms

Loss on drying

Not more than 0.25%

0.35%

Sulphated ash

Not more than 0.1%.

0.07%

Assay

97.0~103.0%

99.16%

Conclusion Qualified

Medical Uses:

Human Use

Nitrofurazone was previously available as a prescription in the U.S., and was indicated as a topical solution, topical cream, or topical ointment for the treatment of bacterial skin infections, wounds, burns, and ulcers.It was also used as a prophylactic measure to prevent infection that could potentially result in skin graft rejection.

Animal Use

Nitrofurazone is indicated for topical use in dogs, cats, and horses, for the treatment or prophylactic treatment of superficial bacterial infections, burns, and cutaneous ulcers.Preparations for treating infections, such as fin rot, in ornamental fish are also still commercially available.The use of nitrofurazone, or related compounds, in animals raised for human consumption has been strictly banned.

Mechanism Of Action:

The exact mechanism of action is unknown. Furacilin inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase.

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