Veterinary Local Anaesthesia Drugs Parasiticide Moxidectin CAS 113507-06-5 White

Veterinary Drug Parasiticide Moxidectin 113507-06-5 White Powder 98%

Description:

Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasites glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.

Basic information:

Chemical name: Moxidectin
MF: C37H53NO8
MW: 639.825
CAS: 113507-06-5
Appearance: white powder
Purity: over 99%

Medicinal uses:

Dogs: Prevention of heartworm. In combination with imidacloprid to treat sarcoptic mange.
Horses: Treatment of parasites including Strongylus vulgaris, and stomach bots such as Gasterophilus intestinalis.
Cattle: Treatment of parasites such as the gastrointestinal nematode Ostertagia ostertagi, and the lungworm Dictyocaulus viviparus.
Sheep: Treatment of the nematodes Teladorsagia circumcincta and Haemonchus contortus.
Nematodes can develop cross-resistance between moxidectin and other similar parasiticides, such as ivermectin, doramectin and abamectin.

Mechanism of action:

Moxidectin selectively binds to the parasites GABA-A and glutamate-gated chloride ion channels which are vital for the function of invertebrate nerve and muscle cells. It presents activity against the parasite but it does not kill him.Once moxidectin is bound, there is an increased permeability leading to an influx of chloride ions and flaccid paralysis of the parasite.

DOSAGE AND ADMINISTRATION:

Recommended Dosage In Patients Aged 12 Years And Older

The recommended dosage of Moxidectin Tablet is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food.

Storage And Handling:

Moxidectin Tablets containing 2 mg moxidectin are white to pale yellow uncoated oval-shaped tablets, debossed on one side with “AKKA”. Each high-density polyethylene bottle contains 500 tablets (NDC 71705-050-01), a silica gel desiccant and polyester coil.

Store below 30°C (86°F).

Protect from light.
Once open, the full contents of the container should be used within 24 hours with any unused content discarded.

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Veterinary Local Anaesthesia Drugs Parasiticide Moxidectin CAS 113507-06-5 White Images